Translational validity of the serotonergic model of psychosis in rats
It has been proposed that serotonergic hallucinogens can be used to model some aspects of psychosis. The representatives of the two main classes of these compounds – tryptamines (psilocin, LSD) and phenethylamines (mescaline, 2C-B) were used as pharmacological models of psychosis in rats. The psychotic state is characterized by impaired processing of information, which is reflected by a decrement of functional connectivity according to the disconnection theory of schizophrenia. In this study, we measured quantitative EEG in freely moving rats after the administration of serotonergic hallucinogens. This technique enabled us to analyze cortical EEG power and to perform a coherence analysis – a functional connectivity measure.
2011 – 2014: Faculty of Science, Charles University in Prague, Bachelor’s programme: Molecular biology and biochemistry of organisms; 2014 – 2015: Prague Psychiatric Centre, Laboratory of Biochemistry and Brain Pathophysiology; 2014 – present: Faculty of Science, Charles University in Prague, Master’s programme: Animal and human physiology, focus in Neurobiology; 2015 – present: National Institute of Mental Health, Neurobiology of aging, addiction and severe mental disorders, Training in EEG and epileptology