Psilocybin Administration in Clinical Trial: Acute Effects, Long-term Effects and Perception of Music
The serotonergic hallucinogen psilocybin has profound effects on the human mind with a potential in the treatment of some psychiatric disorders. Twenty volunteers completed the psilocybin session in a double-blind, placebo-controlled arrangement. This study describes the phenomenology, physiological parameters, pharmacokinetics of psilocybin intoxication and focuses on electrophysiological measures of brain activity. Psilocybin decreased the EEG spectral power in alpha frequency band, however increased the power of gamma oscillations. EEG findings will be correlated with neuropsychiatric scales. We confirmed the safety and beneficial effects of psilocybin administration under controlled conditions. These findings will help facilitate future clinical trials using psychedelics in patients.
Filip Tyls (1985, Prague, Czech Republic) is a psychiatrist and neuroscientist with main interest in translational mopdels of acute psychosis and psychedelic substances. He completed 1st medical faculty and currently is PhD student in neurosciences on 3rd medical faculty on Charles University in Prague. He recieved a specialization in electroencephalography and is in training of Gestalt psychotherapy. He has experiences as psychedelic sitter in a team working on pilot clinical trial with psilocybin in Czech Republic.