ERPs (P300, mismatch negativity) reveal altered cognitive processing during psilocybin intoxication
Neurocognitive impairments such as impaired attention, memory or executive functions are a hallmark feature of psychotic disorders. In order to investigate the extent of cognitive disruption during psilocybin intoxication, auditory sensory memory and information processing were evaluated by means of event-related potentials (mismatch negativity – MMN, P300). In a placebo-controlled design, 20 healthy adults were administered a dose of psilocybin per os (0,26 mg/kg) and placebo during 2 separate sessions. 90 and 125 minutes after the ingestion event-related potentials (P300 and MMN respectively) were recorded. The latency and the amplitude of the P300 wave were significantly affected by psilocybin while there were no significant changes observed for the MMN component. Our findings are in line with previous studies showing that psilocybin does not affect processing at the level of the auditory sensory memory but induces abnormalities in higher-order cognition.
After completing UCL-Yale MSc programme in Psychodynamic Developmental Neuroscience, Michaela focused on the use of ERPs in human pharmacological models of psychosis. Currently she pursues a PhD in Neuroscience at 3rd Medical Faculty of Charles University in Prague and works as a researcher and psychologist at the EEG laboratory of the National Institute of Mental Health in Czech Republic. Most recently, Michaela has entered a training in psychoanalytic psychotherapy at the Czech Society for Psychoanalytic Psychotherapy.