Acute effects of LSD in a placebo-controlled study in humans
LSD (lysergic acid diethylamide) is a classic hallucinogen. It was widely studied in the 1950s to 1970s as an adjunct to psychotherapy. Today, LSD is again in the focus of several investigations ranging from pharmacological research studies in healthy subjects to studies investigating LSD as an adjunct in psychotherapy.
A random order 2-period cross-over design (100 µg LSD vs. Placebo) was used in 24 healthy subjects. Subjective effects and autonomic effects were measured. Additionally, we investigated the effects of LSD on the processing of emotional information.
LSD did moderately increase systolic and diastolic blood pressure, body temperature, and pupil size. In addition to alterations in perception, LSD produced overall positive subjective feelings of closeness to others, openness, and trust. LSD also reduced the recognition of sad and fearful faces.
LSD induced positive subjective effects and empathogenic effects in a controlled setting.
Grown up in Singapore and moved to Switzerland in 1992. Completed college at the Swiss Olympic Sport Schools in 2008 and deepened his formation in the field of sports and nutrition in the following years. Due to his interest, not only in the anatomy and physiology of the human body, but also in the basic cellular mechanisms he started his studies in pharmaceutical sciences at the University of Basel. In 2013 he wrote his master thesis in the group of Prof. Liechti and Prof. Rentsch and thereby got first contact with clinical studies using psychoactive substances in humans. In 2014, he started his PhD at the division of clinical pharmacology & toxicology in the group of Prof. Matthias Liechti and since then has conducted clinical studies with psychoactive substances such as MDMA, LSD, and d-amphetamine. His main focus is on the acute effects of LSD in healthy volunteers but he also develops the analytical methods to obtain pharmacokinetic information on LSD.